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Posted By Admin @ Mar 02, 2022
Posted By Admin @ Mar 02, 2022
Tittle: report on Safinamide uses, mechanism and side effects
Before knowing about the uses, mechanism and side-effects it is compulsory to know about the word safinamide in detail that what it is. There are many people who are not well aware of this word so, before digging further about it. Let’s start with the basic.
What is Safinamide?
It is a scientific word related with the medical, it is a monoamine oxidase inhibitor of type B and it is usually known from its short form which is (MAO-B). Next thing is its working, it works simply by allowing a chemical called with a name of dopamine which is present in the brain. This safinamide works with the dopamine so that it can work for the longer time duration, its effects remain for a long interval in short. As all of us know that when the level of dopamine reduces in the brain it leads towards a disease called as Parkinson’s disease. (Jancovic J 2008).
This safinamide is mostly given with other medicines like carbidopa and levodopa to make sure that muscle stiffness and loss of control (which usually happens in Parkinson’s disease) become better by its use.
Clinical use of safinamide in the treatment of Parkinson’s disease:
Parkinson Disease which can also be called as PD, it is considered to be the second common neurodegenerative disorder. Death of the neurons take place or they can become inactive in the brain of the body. This disease effects the motion of a person. Some of the recent studies revealed that this disease is caused by the mutation in single gene. Genetic analyses came to know that the linkage to six regions of chromosome and also identified that three causative genes are present which are:
Due to the presence of this disease, it involves the malfunction and death of many nerve cells in the brain which are known as neurons. Parkinson firstly affects the neurons in the area of the brain known as substantia nigari. Some neurons which dies produces a chemical known as Dopamine. It is a chemical which sends the messages to the part of the brain which controls the movement and coordination. This chemical is very much important but as the Parkinson disease progresses the amount of dopamine produced in the brain decreases, which makes the person unable to control the movement normally.
Some scientists are also working and exploring on the idea that the loss and decrease of cells in other parts of the brain and body contributes to Parkinson disease.
For example researchers have concluded that the hallmark sign of Parkinson disease (clumps of protein alpha synuclein) also known as Lewy bodies are not only present in the mid brain but also in the brain stem and olfactory bulb. (Chaudhuri KR , Shapira AH 2009)
• Tremor, or shaking, often in a hand, arm, or leg, occurs when you're awake and sitting or standing still (resting tremor).
• It gets better when you move that body part.
• Tremor is often the first symptom that people with Parkinson's disease or their family members notice.
• This takes place when person bends the body part like arm or leg.
• Movement of these body parts is not smooth.
• Slowed down movement.
• Problems with balance.
All the patients who have Parkinson disease don’t show same signs.
Start of this disease varies from person to person. Some people have this disease in young age while some have at the age of 60. This disease is commonly found in men more rather